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Article

AnhE, a metallochaperone involved in the maturation of a cobalt-dependent nitrile hydratase.

The Journal of biological chemistry - 13 Aug 2010

Okamoto Sachi, Van Petegem Filip, Patrauchan Marianna A, Eltis Lindsay D

Abstract excerpt

Acetonitrile hydratase (ANHase) of Rhodococcus jostii RHA1 is a cobalt-containing enzyme with no significant sequence identity with characterized nitrile hydratases. The ANHase structural genes anhA and anhB are separated by anhE, predicted to encode an 11.1-kDa polypeptide. An anhE deletion mutant did not grow on acetonitrile but grew on acetamide, the ANHase reaction product. Growth on acetonitrile was restored...

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Identifiers

PMID: 20558748
DOI: 10.1074/jbc.M110.109223
PMCID: PMC2919074

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