Article
Alternative splicing of CD200 is regulated by an exonic splicing enhancer and SF2/ASF.
Nucleic acids research - 1 Oct 2010
Chen Zhiqi, Ma Xuezhong, Zhang Jianhua, Hu Jim, Gorczynski Reginald M
Abstract excerpt
CD200, a type I membrane glycoprotein, plays an important role in prevention of inflammatory disorders, graft rejection, autoimmune diseases and spontaneous fetal loss. It also regulates tumor immunity. A truncated CD200 (CD200(tr)) resulting from alternative splicing has been identified and characterized as a functional antagonist to full-length CD200. Thus, it is important to explore the mechanism(s)...
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