Article
Regulation of hemolysin expression and virulence of Staphylococcus aureus by a serine/threonine kinase and phosphatase.
PloS one - 11 Jun 2010
Burnside Kellie, Lembo Annalisa, de Los Reyes Melissa, Iliuk Anton, Binhtran Nguyen-Thao, Connelly James E, Lin Wan-Jung, Schmidt Byron Z, Richardson Anthony R, Fang Ferric C, Tao Weiguo Andy, Rajagopal Lakshmi
Abstract excerpt
Exotoxins, including the hemolysins known as the alpha (alpha) and beta (beta) toxins, play an important role in the pathogenesis of Staphylococcus aureus infections. A random transposon library was screened for S. aureus mutants exhibiting altered hemolysin expression compared to wild type. Transposon insertions in 72 genes resulting in increased or decreased hemolysin expression were identified. Mutations...
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