Article
Characterization of a serine/threonine kinase involved in virulence of Staphylococcus aureus.
Journal of bacteriology - 1 Jul 2009
Débarbouillé Michel, Dramsi Shaynoor, Dussurget Olivier, Nahori Marie-Anne, Vaganay Elisabeth, Jouvion Grégory, Cozzone Alain, Msadek Tarek, Duclos Bertrand
Abstract excerpt
Staphylococcus aureus is a common human cutaneous and nasal commensal and a major life-threatening pathogen. Adaptation to the different environments encountered inside and outside the host is a crucial requirement for survival and colonization. We identified and characterized a eukaryotic-like serine/threonine kinase with three predicted extracellular PASTA domains (SA1063, or Stk1) and its associated...
Topics
- Animals
- Bacterial Proteins
- Cell Membrane
- Female
- Fosfomycin
- Genetic Complementation Test
- Immunoblotting
- Manganese
- Mice
- Mutagenesis, Site-Directed
- Mutation
- Octoxynol
- Operon
- Protein Serine-Threonine Kinases