Article
Ribosylurea accumulates in yeast urc4 mutants.
Nucleosides, nucleotides & nucleic acids - 1 Jun 2010
Björnberg O, Vodnala M, Domkin V, Hofer A, Rasmussen A, Andersen G, Piskur J
Abstract excerpt
Yeast Saccharomyces (Lachancea) kluyveri urc4 mutants, unable to grow on uracil, biotransformed (14)C(2)-uracil into two labeled compounds, as detected by high performance liquid chromatography (HPLC). These two compounds could also be obtained following organic synthesis of ribosylurea. This finding demonstrates that in the URC pyrimidine degradation pathway, the opening of the uracil ring takes place when...
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