Article
Evaluation of non-synonymous NPPA single nucleotide polymorphisms in atrial fibrillation.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 1 Aug 2010
Roberts Jason D, Davies Robert W, Lubitz Steven A, Thibodeau Isabelle L, Nery Pablo B, Birnie David H, Benjamin Emelia J, Lemery Robert, Ellinor Patrick T, Gollob Michael H
Abstract excerpt
AIMS: Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is an important cause of morbidity and mortality. A genetic mutation in the NPPA gene, which encodes the atrial natriuretic peptide, has been identified as the putative causative factor in a family with an autosomal dominant pattern of inheritance for AF. Two common single nucleotide polymorphisms (SNPs) in NPPA, rs5063 and rs5065,...
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