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Article

Apoptosis induction after herpes simplex virus infection differs according to cell type in vivo.

Archives of virology - 1 Aug 2010

Esaki Shinichi, Goshima Fumi, Katsumi Sachiyo, Watanabe Daisuke, Ozaki Noriyuki, Murakami Shingo, Nishiyama Yukihiro

Abstract excerpt

We compared apoptosis induction in mice following three routes of infection. After intravenous infection, wild-type herpes simplex virus (HSV) types 1 and 2 and US3Delta mutants infected the adrenal gland and caused apoptosis. Corneal infection with wild-type virus resulted in apoptosis in a fraction of infected epithelium cells. Interestingly, many uninfected cells were apoptotic in the retina. Although neurons...

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Identifiers

PMID: 20535504
DOI: 10.1007/s00705-010-0712-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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