Article
Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2010
Marozkina Nadzeya V, Yemen Sean, Borowitz Molly, Liu Lei, Plapp Melissa, Sun Fei, Islam Rafique, Erdmann-Gilmore Petra, Townsend R Reid, Lichti Cheryl F, Mantri Sneha, Clapp Phillip W, Randell Scott H, Gaston Benjamin, Zaman Khalequz
Abstract excerpt
The endogenous signaling molecule S-nitrosoglutathione (GSNO) and other S-nitrosylating agents can cause full maturation of the abnormal gene product DeltaF508 cystic fibrosis (CF) transmembrane conductance regulator (CFTR). However, the molecular mechanism of action is not known. Here we show th...
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