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Article

Induction of HSP70 promotes DeltaF508 CFTR trafficking.

American journal of physiology. Lung cellular and molecular physiology - 1 Jul 2001

Choo-Kang L R, Zeitlin P L

Abstract excerpt

The DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) is a temperature-sensitive trafficking mutant that is detected as an immature 160-kDa form (band B) in gel electrophoresis. The goal of this study was to test the hypothesis that HSP70, a member of the 70-kDa heat shock prot...

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Source

Identifiers

PMID: 11404246
DOI: 10.1152/ajplung.2001.281.1.L58

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11404246-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Induction of HSP70 promotes DeltaF508 CFTR trafficking.PMID 11404246Read ↗

Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR.Semantic proximity Read ↗

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Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line demonstrates a major influence on heat-shock proteinsSemantic proximity Read ↗

Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epitheliaSemantic proximity Read ↗

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Activation of the unfolded protein response by deltaF508 CFTR.Semantic proximity Read ↗

The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment.Semantic proximity Read ↗

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Chemical chaperones correct the mutant phenotype of the delta F508 cystic fibrosis transmembrane conductance regulator protein.Semantic proximity Read ↗

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