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Article

Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis.

Cancer research - 15 Jun 2010

Valastyan Scott, Chang Amelia, Benaich Nathan, Reinhardt Ferenc, Weinberg Robert A

Abstract excerpt

miR-31 inhibits breast cancer metastasis via the pleiotropic suppression of a cohort of prometastatic target genes that include integrin alpha(5) (ITGA5), radixin (RDX), and RhoA. We previously showed that the concomitant overexpression of ITGA5, RDX, and RhoA was capable of overriding the antime...

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Source

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Identifiers

PMID: 20530680
DOI: 10.1158/0008-5472.CAN-10-0410
PMCID: PMC2891350

Genes

ITGA5
RDX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20530680-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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