Article
Common variants in FOXP1 are associated with generalized vitiligo.
Nature genetics - 1 Jul 2010
Jin Ying, Birlea Stanca A, Fain Pamela R, Mailloux Christina M, Riccardi Sheri L, Gowan Katherine, Holland Paulene J, Bennett Dorothy C, Wallace Margaret R, McCormack Wayne T, Kemp E Helen, Gawkrodger David J, Weetman Anthony P, Picardo Mauro, Leone Giovanni, Taïeb Alain, Jouary Thomas, Ezzedine Khaled, van Geel Nanny, Lambert Jo, Overbeck Andreas, Spritz Richard A
Abstract excerpt
In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P=1.04x10(-8)) and with variants at...
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