Article
Nonsenescent Hsp27-upregulated MSCs implantation promotes neuroplasticity in stroke model.
Cell transplantation - 1 Jan 2010
Liu Shih-Ping, Ding Dah-Ching, Wang Hsiao-Jung, Su Ching-Yuan, Lin Shinn-Zong, Li Hung, Shyu Woei-Cherng
Abstract excerpt
Cellular senescence induces changes in cellular physiology, morphology, proliferative capacity, and gene expression. Stem cell senescence might be one of the major issues of limited efficacy of stem cell transplantation. In this study, we demonstrated that implantation of human umbilical cord mesenchymal stem cells (hUCMSCs) cultured in human umbilical cord serum (hUCS) significantly enhanced neuroplasticity and...
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