Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.

Annals of neurology - 1 Jun 2010

Deng Han-Xiang, Zhai Hong, Bigio Eileen H, Yan Jianhua, Fecto Faisal, Ajroud Kaouther, Mishra Manjari, Ajroud-Driss Senda, Heller Scott, Sufit Robert, Siddique Nailah, Mugnaini Enrico, Siddique Teepu

Abstract excerpt

OBJECTIVE: Amyotrophic lateral sclerosis (ALS) is a fatal disorder of motor neuron degeneration. Most cases of ALS are sporadic (SALS), but about 5 to 10% of ALS cases are familial (FALS). Recent studies have shown that mutations in FUS are causal in approximately 4 to 5% of FALS and some apparent SALS cases. The pathogenic mechanism of the mutant FUS-mediated ALS and potential roles of FUS in non-FUS ALS remain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Transformed
Share to Frontotemporal Lobar Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inclusion Bodies

Share to Microscopy, Confocal

Share to RNA-Binding Protein FUS

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Share to Ubiquitin

Source

Open in PubMed Open full text

Identifiers

PMID: 20517935
DOI: 10.1002/ana.22051
PMCID: PMC4376270

Genes

FUS
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.PMID 20517935Read ↗

FUS mutations in amyotrophic lateral sclerosis: clinical, pathological, neurophysiological and genetic analysisSemantic proximity Read ↗

Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation.Semantic proximity Read ↗

Frameshift and novel mutations in <i>FUS</i> in familial amyotrophic lateral sclerosis and ALS/dementiaSemantic proximity Read ↗

Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis.Semantic proximity Read ↗

ALS-FUS pathology revisited: singleton FUS mutations and an unusual case with both a FUS and TARDBP mutation.Semantic proximity Read ↗

A new subtype of frontotemporal lobar degeneration with FUS pathology.Semantic proximity Read ↗

[Clinical and pathological characteristics of FUS/TLS-associated amyotrophic lateral sclerosis (ALS)].Semantic proximity Read ↗

Identification of novel FUS mutations in sporadic cases of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashionSemantic proximity Read ↗

Amyotrophic lateral sclerosis and non-tau frontotemporal lobar degeneration.Semantic proximity Read ↗

Novel FUS/TLS mutations and pathology in familial and sporadic amyotrophic lateral sclerosis.Semantic proximity Read ↗

Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.