Article
Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit.
Neurology - 1 Jun 2010
Eggers C, Schmidt A, Hagenah J, Brüggemann N, Klein J C, Tadic V, Kertelge L, Kasten M, Binkofski F, Siebner H, Neumaier B, Fink G R, Hilker R, Klein C
Abstract excerpt
BACKGROUND: While homozygous mutations in the PINK1 gene cause recessively inherited early-onset Parkinson disease (PD), heterozygous mutations have been suggested as a susceptibility factor. METHODS: To evaluate this hypothesis, 4 homozygous PINK1 patients with PD and 10 asymptomatic carriers of...
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