Article
PINK1 mutations and parkinsonism.
Neurology - 16 Sept 2008
Ishihara-Paul L, Hulihan M M, Kachergus J, Upmanyu R, Warren L, Amouri R, Elango R, Prinjha R K, Soto A, Kefi M, Zouari M, Sassi S B, Yahmed S B, El Euch-Fayeche G, Matthews P M, Middleton L T, Gibson R A, Hentati F, Farrer M J
Abstract excerpt
BACKGROUND: PINK1 loss-of-function causes recessive, early-onset parkinsonism. In Tunisia there is a high rate of consanguineous marriage but PINK1 carrier frequency and disease prevalence have yet to be assessed. OBJECTIVES: The frequency of PINK1 mutations in familial parkinsonism, community-based patients with idiopathic Parkinson disease (PD) (non-familial PD), and control subjects was determined. Demographic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.