Role of MrkJ, a phosphodiesterase, in type 3 fimbrial expression and biofilm formation in Klebsiella pneumoniae.

doi:10.1128/JB.00304-10

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Article

Role of MrkJ, a phosphodiesterase, in type 3 fimbrial expression and biofilm formation in Klebsiella pneumoniae.

Journal of bacteriology - 1 Aug 2010

Johnson Jeremiah G, Clegg Steven

Abstract excerpt

Klebsiella pneumoniae is an opportunistic pathogen that has been shown to adhere to human extracellular matrices using the type 3 fimbriae. Introduction of plasmids carrying genes known to alter intracellular cyclic-di-GMP pools in Vibrio parahaemolyticus revealed that these genes also altered type 3 fimbrial surface expression in K. pneumoniae. Immediately adjacent to the type 3 fimbrial gene cluster is a gene,...

Topics

Biofilms
Escherichia coli Proteins
Fimbriae Proteins
Gene Expression Regulation, Bacterial
Gene Expression Regulation, Enzymologic
Klebsiella pneumoniae
Multigene Family
Mutation
Phosphoric Diester Hydrolases
Phosphorus-Oxygen Lyases
Plasmids
Transcription, Genetic

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Identifiers

PMID: 20511505
DOI: 10.1128/JB.00304-10
PMCID: PMC2916373

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