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Article

Virologic characterization of multidrug-resistant cytomegalovirus infection in 2 transplant recipients treated with maribavir.

The Journal of infectious diseases - 1 Jul 2010

Strasfeld Lynne, Lee Ingi, Tatarowicz Walter, Villano Stephen, Chou Sunwen

Abstract excerpt

The experimental cytomegalovirus UL97 kinase inhibitor maribavir was used to treat 2 cases of infection in which viral mutations that conferred ganciclovir and foscarnet resistance had evolved sequentially. In one case, viral shedding was cleared without evidence of maribavir resistance in an isolate obtained after therapy. In the other case, a high-grade viremia was initially reduced 50-fold but rebounded 2...

Topics

Adult
Aged
Antiviral Agents
Benzimidazoles
Cytomegalovirus
Cytomegalovirus Infections
Female
Heart Transplantation
Humans
Lung Transplantation
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Ribonucleosides

Viral Load

Viremia

Source

Identifiers

PMID: 20504236
DOI: 10.1086/653122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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