Article
Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations.
PloS one - 19 May 2010
Diaz de Leon Alberto, Cronkhite Jennifer T, Katzenstein Anna-Luise A, Godwin J David, Raghu Ganesh, Glazer Craig S, Rosenblatt Randall L, Girod Carlos E, Garrity Edward R, Xing Chao, Garcia Christine Kim
Abstract excerpt
BACKGROUND: Telomerase is an enzyme that catalyzes the addition of nucleotides on the ends of chromosomes. Rare loss of function mutations in the gene that encodes the protein component of telomerase (TERT) have been described in patients with idiopathic pulmonary fibrosis (IPF). Here we examine the telomere lengths and pulmonary fibrosis phenotype seen in multiple kindreds with heterozygous TERT mutations....
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