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Dyskerin Ablation in Mouse Liver Inhibits rRNA Processing and Cell Division

16 Nov 2009

Abstract excerpt

Dyskerin is a component of small nucleolar ribonucleoprotein complexes and acts as a pseudouridine synthase to modify newly synthesized ribosomal, spliceosomal, and possibly other RNAs. It is encoded by the DKC1 gene, the gene mutated in X-linked dyskeratosis congenita, and is also part of the telomerase complex. The yeast ortholog, Cbf5, is an essential protein, but in mammals the effect of dyskerin ablation at...

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PMID: 19917719
DOI: 10.1128/mcb.01128-09

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