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Article

Val-9Ala and Ile+58Thr polymorphism of MnSOD in Parkinson's disease.

Clinical biochemistry - 1 Aug 2010

Wang Vinchi, Chen Shao-Yuan, Chuang Tzu-Chao, Shan Din-E, Soong Bing-Wen, Kao Ming-Ching

Abstract excerpt

OBJECTIVES: To investigate the polymorphism distribution of Val-9Ala and Ile+58Thr of the Mn-superoxide dismutase (Mn-SOD) gene among subjects with Parkinson's disease (PD) by analyses of genders and clinical severity. DESIGN AND METHODS: We examined the DNA genotypes of Val-9Ala and Ile+58Thr from 295 PD subjects and 111 controls by nucleotide sequencing and BsaWI restriction. RESULTS: Ala/Ala homozygosity was...

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PMID: 20501330
DOI: 10.1016/j.clinbiochem.2010.05.009

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