Article
The microcephalin ancestral allele in a Neanderthal individual.
PloS one - 14 May 2010
Lari Martina, Rizzi Ermanno, Milani Lucio, Corti Giorgio, Balsamo Carlotta, Vai Stefania, Catalano Giulio, Pilli Elena, Longo Laura, Condemi Silvana, Giunti Paolo, Hänni Catherine, De Bellis Gianluca, Orlando Ludovic, Barbujani Guido, Caramelli David
Abstract excerpt
BACKGROUND: The high frequency (around 0.70 worldwide) and the relatively young age (between 14,000 and 62,000 years) of a derived group of haplotypes, haplogroup D, at the microcephalin (MCPH1) locus led to the proposal that haplogroup D originated in a human lineage that separated from modern humans >1 million years ago, evolved under strong positive selection, and passed into the human gene pool by an episode...
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