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Article

Low dosage of histone H4 leads to growth defects and morphological changes in Candida albicans.

PloS one - 13 May 2010

Zacchi Lucia F, Selmecki Anna M, Berman Judith, Davis Dana A

Abstract excerpt

Chromatin function depends on adequate histone stoichiometry. Alterations in histone dosage affect transcription and chromosome segregation, leading to growth defects and aneuploidies. In the fungal pathogen Candida albicans, aneuploidy formation is associated with antifungal resistance and pathogenesis. Histone modifying enzymes and chromatin remodeling proteins are also required for pathogenesis. However,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20498713
DOI: 10.1371/journal.pone.0010629
PMCID: PMC2869362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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