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Article

HOS2 and HDA1 encode histone deacetylases with opposing roles in Candida albicans morphogenesis.

PloS one - 13 Aug 2010

Zacchi Lucia F, Schulz Wade L, Davis Dana A

Abstract excerpt

Epigenetic mechanisms regulate the expression of virulence traits in diverse pathogens, including protozoan and fungi. In the human fungal pathogen Candida albicans, virulence traits such as antifungal resistance, white-opaque switching, and adhesion to lung cells are regulated by histone deacetylases (HDACs). However, the role of HDACs in the regulation of the yeast-hyphal morphogenetic transitions, a critical...

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Identifiers

PMID: 20730094
DOI: 10.1371/journal.pone.0012171
PMCID: PMC2921335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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