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Article

Increased plasma membrane cholesterol in cystic fibrosis cells correlates with CFTR genotype and depends on de novo cholesterol synthesis.

Respiratory research - 20 May 2010

Fang Danjun, West Richard H, Manson Mary E, Ruddy Jennifer, Jiang Dechen, Previs Stephen F, Sonawane Nitin D, Burgess James D, Kelley Thomas J

Abstract excerpt

BACKGROUND: Previous observations demonstrate that Cftr-null cells and tissues exhibit alterations in cholesterol processing including perinuclear cholesterol accumulation, increased de novo synthesis, and an increase in plasma membrane cholesterol accessibility compared to wild type controls. Th...

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Source

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Identifiers

PMID: 20487541
DOI: 10.1186/1465-9921-11-61
PMCID: PMC2880018

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20487541-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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