Article
Making a haplotype catalog with estimated frequencies based on SNP homozygotes.
Journal of human genetics - 1 Aug 2010
Yamaguchi-Kabata Yumi, Tsunoda Tatsuhiko, Takahashi Atsushi, Hosono Naoya, Kubo Michiaki, Nakamura Yusuke, Kamatani Naoyuki
Abstract excerpt
Understanding the structure and frequencies of haplotypes is important for associating genetic polymorphisms with a given trait and for inferring the genetic genealogy of alleles in a population. Single nucleotide polymorphism (SNP) haplotypes can be determined without ambiguity when an individual does not have more than one heterozygous site in a given genomic region. Using genome-wide SNP genotypes for 3397...
Topics
- Asian People
- Gene Frequency
- Genome, Human
- Genome-Wide Association Study
- Genotype
- Haplotypes
- Homozygote
- Humans
- Linkage Disequilibrium
- Mathematical Computing
- Phenotype