Article
Making a haplotype catalog with estimated frequencies based on SNP homozygotes.
Journal of human genetics - 1 Aug 2010
Yamaguchi-Kabata Yumi, Tsunoda Tatsuhiko, Takahashi Atsushi, Hosono Naoya, Kubo Michiaki, Nakamura Yusuke, Kamatani Naoyuki
Abstract excerpt
Understanding the structure and frequencies of haplotypes is important for associating genetic polymorphisms with a given trait and for inferring the genetic genealogy of alleles in a population. Single nucleotide polymorphism (SNP) haplotypes can be determined without ambiguity when an individual does not have more than one heterozygous site in a given genomic region. Using genome-wide SNP genotypes for 3397...
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