Article
Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease.
Obesity surgery - 1 Dec 2010
Gawrieh Samer, Baye Tesfaye M, Carless Melanie, Wallace James, Komorowski Richard, Kleiner David E, Andris Deborah, Makladi Bassem, Cole Regina, Charlton Michael, Curran Joanne, Dyer Thomas D, Charlesworth Jac, Wilke Russell, Blangero John, Kissebah Ahmed H, Olivier Michael
Abstract excerpt
BACKGROUND: Genetic factors alter the risk for nonalcoholic fatty liver disease (NAFLD). We sought to identify NAFLD-associated genes and elucidate gene networks and pathways involved in the pathogenesis of NAFLD. METHODS: Quantitative global hepatic gene expression analysis was performed on 53 morbidly obese Caucasian subjects undergoing bariatric surgery (27 with NAFLD and 26 controls). After standardization of...
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