Inhibitory effect of rat immunization with tularemia vaccine on the in vivo clastogenicity of 4 anthracycline antibiotics.

doi:10.1016/0165-1218(91)90010-j

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Inhibitory effect of rat immunization with tularemia vaccine on the in vivo clastogenicity of 4 anthracycline antibiotics.

Mutation research - 1 Jun 1991

Nersessian A K, Zilfian V N, Koumkoumadjian V A

Abstract excerpt

We studied the in vivo effect of rat immunization with tularemia live vaccine (TLV) on chromosomal aberrations (CA) induced in bone marrow cells by 4 anthracycline antibiotics. CA induced by adriamycin (ADR) and 4'-epiadriamycin (EADR) in rat bone marrow cells consisted mainly of chromatid breaks (approximately 90%), whereas lesions induced by aclacur (AC) and aclarubicin (ACR) consisted only of chromatid breaks....

Topics

Aclarubicin
Animals
Antibiotics, Antineoplastic
Bacterial Vaccines
Bone Marrow Cells
Chromosome Aberrations
Doxorubicin
Epirubicin
Francisella tularensis
Injections, Intradermal
Liver

Male

Mutation

Rats

Rats, Inbred Strains

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