Article
High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype.
Histopathology - 1 Feb 2010
Zardawi Sarah J, Zardawi Ibrahim, McNeil Catriona M, Millar Ewan K A, McLeod Duncan, Morey Adrienne L, Crea Paul, Murphy Niamh C, Pinese Mark, Lopez-Knowles Elena, Oakes Samantha R, Ormandy Christopher J, Qiu Min Ru, Hamilton Anne, Spillane Andrew, Soon Lee Cheok, Sutherland Robert L, Musgrove Elizabeth A, O'Toole Sandra A
Abstract excerpt
AIMS: Activation of Notch signalling results in hyperplasia and tumorigenesis in murine mammary epithelium. However, there is little information regarding the expression of Notch1 in premalignant lesions and early breast cancer. We investigated expression of Notch1 in breast cancer development an...
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