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Article

Epigenetic alteration of microRNAs in DNMT3B-mutated patients of ICF syndrome.

Epigenetics - 1 Jul 2010

Gatto Sole, Della Ragione Floriana, Cimmino Amelia, Strazzullo Maria, Fabbri Muller, Mutarelli Margherita, Ferraro Lorenzo, Weisz Alessandro, D'Esposito Maurizio, Matarazzo Maria R

Abstract excerpt

Immunodeficiency, Centromeric region instability, Facial anomalies (ICF; OMIM #242860) syndrome, due to mutations in the DNMT3B gene, is characterized by inheritance of aberrant patterns of DNA methylation and heterochromatin defects. Patients show variable agammaglobulinemia and a reduced number of T cells, making them prone to infections and death before adulthood. Other variable symptoms include facial...

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PMID: 20448464
DOI: 10.4161/epi.5.5.11999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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