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Article

DNMT3B deficiency presenting as severe combined immune deficiency: A case report.

Clinical immunology (Orlando, Fla.) - 1 Jun 2020

Mehawej Cybel, Khalife Hassan, Hanna-Wakim Rima, Dbaibo Ghassan, Farra Chantal

Abstract excerpt

Immunodeficiency, Centromeric instability and Facial anomalies (ICF) syndrome is a group of rare autosomal recessive disorders. The immune disease in the ICF syndrome consists mainly of humoral immunodeficiency. T-cell dysfunction has previously been suspected to be part of the syndrome's spectrum. However, patients with ICF display, at a young age, a normal number of T cells that tend to decline throughout...

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PMID: 32360517
DOI: 10.1016/j.clim.2020.108453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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