Article
Cardiac sympathetic denervation precedes nigrostriatal loss in the E46K mutation of the alpha-synuclein gene (SNCA).
Clinical autonomic research : official journal of the Clinical Autonomic Research Society - 1 Aug 2010
Tijero B, Gomez-Esteban J C, Llorens V, Lezcano E, Gonzalez-Fernández M C, de Pancorbo M Martinez, Ruiz-Martinez J, Cembellin J C, Zarranz J J
Abstract excerpt
INTRODUCTION: Here we report the case of an asymptomatic carrier of the E46K substitution in alpha-synuclein gene where we have documented that cardiac sympathetic denervation precedes nigrostriatal dopaminergic loss. MATERIAL AND METHODS: She has been followed up regularly with standard neurological examination, UPDRS, neuropsychological formal testing, parkinson disease sleep scale-PDSS, Epworth scale,...
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