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Article

Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning.

Neuron - 29 Apr 2010

Fritsch Brita, Reis Janine, Martinowich Keri, Schambra Heidi M, Ji Yuanyuan, Cohen Leonardo G, Lu Bai

Abstract excerpt

Despite its increasing use in experimental and clinical settings, the cellular and molecular mechanisms underlying transcranial direct current stimulation (tDCS) remain unknown. Anodal tDCS applied to the human motor cortex (M1) improves motor skill learning. Here, we demonstrate in mouse M1 slices that DCS induces a long-lasting synaptic potentiation (DCS-LTP), which is polarity specific, NMDA receptor...

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Identifiers

PMID: 20434997
DOI: 10.1016/j.neuron.2010.03.035
PMCID: PMC2864780

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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