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Article

Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer

27 Apr 2010

Abstract excerpt

BACKGROUND: Side population (SP) fraction cells, identified by efflux of Hoechst dye, are present in virtually all normal and malignant tissues. The relationship between SP cells, drug resistance and cancer stem cells is poorly understood. Small-cell lung cancer (SCLC) is a highly aggressive human tumour with a 5-year survival rate of <10%. These features suggest enrichment in cancer stem cells. METHODS AND...

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PMID: 20424609
DOI: 10.1038/sj.bjc.6605668

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