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Article

Novel etiological and therapeutic strategies for neurodiseases: epigenetic understanding of gene-environment interactions.

Journal of pharmacological sciences - 1 Jan 2010

Kubota Takeo, Miyake Kunio, Hirasawa Takae, Nagai Kaoru, Koide Tsuyoshi

Abstract excerpt

Epigenetics is a mechanism that regulates gene expression not depending on the underlying DNA sequence, but on the chemical modifications of DNA and histone proteins. Defects in the factors involved in epigenetic regulation cause congenital neurodevelopmental diseases, and thus, epigenetic regulation is essential for normal brain development. Besides these intrinsic defects, it is becoming increasingly apparent...

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Identifiers

PMID: 20424390
DOI: 10.1254/jphs.09r20fm

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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