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Article

Dysregulation of kallikrein-related peptidases in renal cell carcinoma: potential targets of miRNAs

24 Feb 2010

Abstract excerpt

Renal cell carcinoma (RCC) accounts for 3% of all adult malignancies and currently no diagnostic marker exists. Kallikrein-related peptidases (KLKs) have been implicated in numerous cancers including ovarian, prostate, and breast carcinoma. KLKs 5, 6, 10, and 11 have decreased expression in RCC when compared to normal kidney tissue. Our bioinformatic analysis indicated that the KLK 1, 6, and 7 genes have...

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PMID: 20180642
DOI: 10.1515/bc.2010.041

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