Article
Significant association of high-risk human papillomavirus (HPV) but not of p53 polymorphisms with oral squamous cell carcinomas in Malaysia.
Journal of cancer research and clinical oncology - 1 Feb 2011
Saini Rajan, Tang Thean-Hock, Zain Rosnah Binti, Cheong Sok Ching, Musa Kamarul Imran, Saini Deepti, Ismail Abdul Rashid, Abraham Mannil Thomas, Mustafa Wan Mahadzir Wan, Santhanam Jacinta
Abstract excerpt
PURPOSE: The purpose of this study was to evaluate the role of HPV and p53 polymorphisms in oral squamous cell carcinomas (OSCC) affecting Malaysian population. METHODS: We analysed frozen samples from 105 OSCC as well as 105 oral specimens derived from healthy individuals. PCR assays targeting two regions of the virus were used. PCR amplification for the analysis of p53 codon 72 arginine/proline alleles was...
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