Article
Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Human molecular genetics - 15 Jul 2010
Wang Xianshu, Pankratz V Shane, Fredericksen Zachary, Tarrell Robert, Karaus Mary, McGuffog Lesley, Pharaoh Paul D P, Ponder Bruce A J, Dunning Alison M, Peock Susan, Cook Margaret, Oliver Clare, Frost Debra, Sinilnikova Olga M, Stoppa-Lyonnet Dominique, Mazoyer Sylvie, Houdayer Claude, Hogervorst Frans B L, Hooning Maartje J, Ligtenberg Marjolijn J, Spurdle Amanda, Chenevix-Trench Georgia, Schmutzler Rita K, Wappenschmidt Barbara, Engel Christoph, Meindl Alfons, Domchek Susan M, Nathanson Katherine L, Rebbeck Timothy R, Singer Christian F, Gschwantler-Kaulich Daphne, Dressler Catherina, Fink Anneliese, Szabo Csilla I, Zikan Michal, Foretova Lenka, Claes Kathleen, Thomas Gilles, Hoover Robert N, Hunter David J, Chanock Stephen J, Easton Douglas F, Antoniou Antonis C, Couch Fergus J
Abstract excerpt
Recent studies have identified single nucleotide polymorphisms (SNPs) that significantly modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. Since these risk modifiers were originally identified as genetic risk factors for breast cancer in genome-wide association studies (GWASs), addi...
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