Article
Succinate dehydrogenase gene mutations are strongly associated with paraganglioma of the organ of Zuckerkandl.
Endocrine-related cancer - 1 Sept 2010
Lodish Maya B, Adams Karen T, Huynh Thanh T, Prodanov Tamara, Ling Alex, Chen Clara, Shusterman Suzanne, Jimenez Camilo, Merino Maria, Hughes Marybeth, Cradic Kendall W, Milosevic Dragana, Singh Ravinder J, Stratakis Constantine A, Pacak Karel
Abstract excerpt
Organ of Zuckerkandl paragangliomas (PGLs) are rare neuroendocrine tumors that are derived from chromaffin cells located around the origin of the inferior mesenteric artery extending to the level of the aortic bifurcation. Mutations in the genes encoding succinate dehydrogenase subunits (SDH) B, C, and D (SDHx) have been associated with PGLs, but their contribution to PGLs of the organ of Zuckerkandl PGLs is not...
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