Article
A new potential oncogenic mutation in the FERM domain of JAK2 in BCR/ABL1-negative and V617F-negative chronic myeloproliferative neoplasms revealed by a comprehensive screening of 17 tyrosine kinase coding genes.
Cancer genetics and cytogenetics - 1 May 2010
Aranaz Paula, Ormazábal Cristina, Hurtado Cristina, Erquiaga Ignacio, Calasanz Maria J, García-Delgado Marina, Novo Francisco J, Vizmanos José L
Abstract excerpt
BCR/ABL1-negative chronic myeloproliferative neoplasms (CMPNs) are a heterogeneous group of clonal hematological malignancies. Over recent years, some genetic events in tyrosine kinase (TK) genes have been described as causal events of these diseases. To identify new genetic aberrations underlying these diseases, we used denaturing high performance liquid chromatography and fluorescence in situ hybridization...
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