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Article

Influence of a mutation in the putative nucleotide binding site of the nitrogen regulatory protein NTRC on its positive control function.

Nucleic acids research - 11 May 1991

Austin S, Kundrot C, Dixon R

Abstract excerpt

A mutation, serine 170 to alanine, in the proposed ATP binding site of the activator protein NTRC prevents transcriptional activation at sigma 54-dependent promoters both in vivo and in vitro. The rate of phosphorylation of the mutant protein by NTRB and the stability of mutant NTRC-phosphate were similar to those of wild-type NTRC. The phosphorylated mutant protein shows only a slight decrease in affinity...

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Identifiers

PMID: 2041769
DOI: 10.1093/nar/19.9.2281
PMCID: PMC329431

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