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Article

Decreased alternative splicing of estrogen receptor-α mRNA in the Alzheimer's disease brain.

Neurobiology of aging - 1 Feb 2012

Ishunina Tatjana A, Swaab Dick F

Abstract excerpt

In this study we identified 62 estrogen receptor alpha (ERα) mRNA splice variants in different human brain areas of Alzheimer's disease (AD) and control cases and classified them into 12 groups. Forty-eight of these splice forms were identified for the first time. The distribution of alternatively spliced ERα mRNAs was brain area- and case-specific. The dominant negative deletion (del.) 7 isoform appeared to be...

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PMID: 20417581
DOI: 10.1016/j.neurobiolaging.2010.03.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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