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The Human Brain Has Distinct Regional Expression Patterns of Estrogen Receptor α mRNA Isoforms Derived from Alternative Promoters

1 Oct 2000

Abstract excerpt

The human estrogen receptor (ER) alpha gene is transcribed from multiple promoters, generating mRNA isoforms with unique 5' ends in the untranslated region. In the present study, alternative promoters were shown to regulate the ERalpha gene expression in different neuronal populations of the human brain. By using in situ hybridization histochemistry, the A and B promoters, but not the C promoter, in the ERalpha...

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PMID: 10987818
DOI: 10.1046/j.1471-4159.2000.0751390.x

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