Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis.

doi:10.1016/j.neurobiolaging.2010.03.007

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Article

Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis.

Neurobiology of aging - 1 Feb 2012

Bogaert Elke, Goris An, Van Damme Philip, Geelen Veerle, Lemmens Robin, van Es Michael A, van den Berg Leonard H, Sleegers Kristel, Verpoorten Nathalie, Timmerman Vincent, De Jonghe Peter, Van Broeckhoven Christine, Traynor Bryan J, Landers John E, Brown Robert H, Glass Jonathan D, Al-Chalabi Ammar, Shaw Christopher E, Birve Anna, Andersen Peter M, Slowik Agnieszka, Tomik Barbara, Melki Judith, Robberecht Wim, Van Den Bosch Ludo

Abstract excerpt

Excitotoxicity is thought to play a pathogenic role in amyotrophic lateral sclerosis (ALS). Excitotoxic motor neuron death is mediated through the Ca(2+)-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type of glutamate receptors and Ca(2+) permeability is determined by the GluR2 subunit. We investigated whether polymorphisms or mutations in the GluR2 gene (GRIA2) predispose patients to...

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Identifiers

PMID: 20409611
DOI: 10.1016/j.neurobiolaging.2010.03.007
PMCID: PMC2949683

Genes

GRIA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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