Article
A toxic shock syndrome toxin mutant of Staphylococcus aureus isolated by allelic replacement lacks virulence in a rabbit uterine model.
FEMS microbiology letters - 1 Mar 1991
Sloane R, de Azavedo J C, Arbuthnott J P, Hartigan P J, Kreiswirth B, Novick R, Foster T J
Abstract excerpt
The gene coding for toxic shock syndrome toxin-1 in S. aureus was inactivated by allelic replacement in two TSS-associated strains. One mutant derived from FRI1169 (a non-enterotoxigenic strain) lacked virulence in the rabbit uterine chamber infection model. This suggests that TSST-1 is the only...
Topics
- Alleles
- Animals
- Bacterial Toxins
- Cloning, Molecular
- Enterotoxins
- Female
- Immunoblotting
- Mutagenesis, Site-Directed
- Mutation
- Rabbits
- Restriction Mapping
- Shock, Septic
- Staphylococcus aureus
- Superantigens
- Uterus
- Virulence