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Article

Characterization of the Schizosaccharomyces pombe orthologue of the human survival motor neuron (SMN) protein.

Human molecular genetics - 22 Mar 2000

Owen N, Doe C L, Mellor J, Davies K E

Abstract excerpt

Childhood onset spinal muscular atrophy (SMA) is a common autosomal recessive disorder primarily characterized by the loss of lower alpha motor neurons. The underlying chromosomal defects causing SMA have been found in the survival motor neuron (SMN) gene. SMN has been shown previously to play a...

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Identifiers

PMID: 10749974
DOI: 10.1093/hmg/9.5.675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10749974-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the Schizosaccharomyces pombe orthologue of the human survival motor neuron (SMN) protein.PMID 10749974Read ↗

Missense mutation clustering in the survival motor neuron gene: a role for a conserved tyrosine and glycine rich region of the protein in RNA metabolism?Semantic proximity Read ↗

Specific splicing defects in S. pombe carrying a degron allele of the Survival of Motor Neuron gene.Semantic proximity Read ↗

Characterization of a gene encoding survival motor neuron (SMN)-related protein, a constituent of the spliceosome complexSemantic proximity Read ↗

The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis.Semantic proximity Read ↗

A novel human-specific splice isoform alters the critical C-terminus of Survival Motor Neuron proteinSemantic proximity Read ↗

The SMN Complex at the Crossroad between RNA Metabolism and NeurodegenerationSemantic proximity Read ↗

The survival motor neuron gene smn-1 interacts with the U2AF large subunit gene uaf-1 to regulate Caenorhabditis elegans lifespan and motor functions.Semantic proximity Read ↗

SMA-causing missense mutations in survival motor neuron (Smn) display a wide range of phenotypes when modeled in Drosophila.Semantic proximity Read ↗

The Schizosaccharomyces pombe protein Yab8p and a novel factor, Yip1p, share structural and functional similarity with the spinal muscular atrophy-associated proteins SMN and SIP1Semantic proximity Read ↗

A Comprehensive Interaction Map of the Human Survival of Motor Neuron (SMN) ComplexSemantic proximity Read ↗

Genome-wide identification of mRNAs associated with the protein SMN whose depletion decreases their axonal localizationSemantic proximity Read ↗

The role of the SMN gene in proximal spinal muscular atrophy.Semantic proximity Read ↗

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