Article
Growth, calcium status and vitamin D receptor (VDR) promoter genotype in European children with normal or low calcium intake.
The Journal of steroid biochemistry and molecular biology - 1 Jul 2010
Jehan Frederic, Voloc Alexandru, Esterle Laure, Walrant-Debray Odile, Nguyen Thi-Minh, Garabedian Michèle
Abstract excerpt
Calcium homeostasis and bone metabolism require the vitamin D receptor (VDR) to function properly, as evidenced in patients and transgenic mice with VDR mutations. We have shown that (A/G) polymorphism at the -1012 locus of the VDR promoter (rs4516035) is frequent in European populations, may influence VDR expression, is associated with height in French adolescent girls, and is associated with their lumbar spine...
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