Article
Two single-nucleotide polymorphisms in the human vitamin D receptor promoter change protein-DNA complex formation and are associated with height and vitamin D status in adolescent girls.
Human molecular genetics - 15 Nov 2005
d'Alésio Arnold, Garabédian Michèle, Sabatier Jean Pierre, Guaydier-Souquières Geneviève, Marcelli Christian, Lemaçon Audrey, Walrant-Debray Odile, Jehan Frédéric
Abstract excerpt
Numerous association studies have dealt with single-nucleotide polymorphisms (SNPs) in coding and intronic regions of the human vitamin D receptor (hVDR) gene. We have hypothesized that phenotypic traits may also be associated with variations in VDR expression due to the presence of SNPs in promoter regions. In this work, we have studied two SNPs located 1521 bp (G/C) and 1012 bp (A/G) upstream of the...
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