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Article

Association between cyclin D1 polymorphism with CpG island promoter methylation status of tumor suppressor genes in gastric cancer.

Digestive diseases and sciences - 1 Dec 2010

Tahara Tomomitsu, Shibata Tomoyuki, Nakamura Masakatsu, Yamashita Hiromi, Yoshioka Daisuke, Okubo Masaaki, Yonemura Joh, Maeda Yoshiteru, Maruyama Naoko, Kamano Toshiaki, Kamiya Yoshio, Fujita Hiroshi, Nakagawa Yoshihito, Nagasaka Mitsuo, Iwata Masami, Hirata Ichiro, Arisawa Tomiyasu

Abstract excerpt

BACKGROUND: CpG island hypermethylation of tumor suppressor genes is highly involved in gastric carcinogenesis, and enhanced cell proliferation could accelerate this process. Cyclin D1 regulates cell cycle function and may play a role in methylation-related carcinogenesis. AIMS: We investigated the association between Cyclin D1 gene G870A polymorphism and the methylation status of tumor suppressor genes in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Kaplan-Meier Estimate

Share to Polymorphism, Genetic

Share to Polymorphism, Restriction Fragment Length

Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 20397048
DOI: 10.1007/s10620-010-1206-5

Genes

DAP
CCND1
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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