Article
PCB-153 exposure coordinates cell cycle progression and cellular metabolism in human mammary epithelial cells.
Toxicology letters - 1 Jul 2010
Venkatesha Venkatasubbaiah A, Kalen Amanda L, Sarsour Ehab H, Goswami Prabhat C
Abstract excerpt
2,2',4,4',5,5'-Hexachlorobiphenyl (PCB-153) is a non-metabolizable environmental chemical contaminant commonly found in breast milk of PCB exposed individuals, suggesting that chronic exposure to PCB-153 could have adverse health effects. We have shown previously that PCB-153 increased reactive oxygen species levels in non-tumorigenic MCF-10A human mammary epithelial cells, which were associated with DNA damage,...
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