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Article

A New Role of the Mosquito Complement-like Cascade in Male Fertility in Anopheles gambiae.

PLoS biology - 1 Jan 2015

Pompon Julien, Levashina Elena A

Abstract excerpt

Thioester-containing protein 1 (TEP1) is a key immune factor that determines mosquito resistance to a wide range of pathogens, including malaria parasites. Here we report a new allele-specific function of TEP1 in male fertility. We demonstrate that during spermatogenesis TEP1 binds to and removes damaged cells through the same complement-like cascade that kills malaria parasites in the mosquito midgut. Further,...

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Source

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Identifiers

PMID: 26394016
DOI: 10.1371/journal.pbio.1002255
PMCID: PMC4579081

Genes

TEP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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